Explosives in Fallout 76 are some of the most versatile tools you can add to your loadout. Whether you’re clearing hordes of Scorched in a Daily Ops mission or trying to gain the upper hand in a heated PvP skirmish, the right grenade can make all the difference. Below, I’ll break down some of the best grenades and explosives for both PvE and PvP, along with tips on how to maximize their effectiveness.

Best Grenades for PvE

Plasma Grenade

Arguably the most reliable explosive in Fallout 76, plasma grenades deliver high energy and ballistic damage in a wide radius. They’re perfect for crowd control against mobs of ghouls or Super Mutants. Pairing them with the Demolition Expert perk can wipe out groups before they even get close.

Nuka Grenade

These are harder to craft and require rarer components, but they pack one of the biggest punches in the game. The large explosion radius makes them excellent for events like Radiation Rumble or Encryptid where enemies spawn in waves. Just be mindful of allies nearby, since friendly fire can be an issue.

Molotov Cocktail

While weaker than other explosives, Molotovs are cheap and plentiful. The fire damage-over-time effect is surprisingly effective against low-health mobs. They’re a great option early on or when you want to conserve more valuable Fallout 76 items for tougher fights.

Best Grenades for PvP

Cryogenic Grenade

In PvP encounters, slowing your opponent is often more valuable than raw damage. Cryogenic grenades freeze enemies in place, giving you time to close the gap or set up a critical shot. They don’t hit as hard as plasma grenades, but their utility is unmatched when dueling other players.

Pulse Grenade

These shine against players using power armor. Pulse grenades deal significant energy damage to machines, making them a great counter for heavily armored foes. If you’re planning on PvP fights around workshops or in the open world, having a few of these can turn the tide.

Frag Grenade

The classic frag grenade remains a staple in PvP due to its availability. While not the strongest, its fast throw speed and predictable arc make it reliable in close quarters. Many experienced players keep them on hand as a backup option when stronger explosives run out.

Tips for Using Explosives

1. Perk Synergy: The Demolition Expert perk is essential if you plan to focus on explosives. It not only boosts damage but also improves your ability to disarm traps.

2. Inventory Management: Explosives are heavy, so don’t overload your stash with too many. Carry what you realistically plan to use.

3. Event Strategy: In PvE events with many allies, avoid tossing high-damage grenades into crowds unless you’re certain you won’t cause unnecessary team damage.

Final Thoughts

Grenades and explosives in Fallout 76 aren’t just flashy tools — they’re strategic assets that can give you a serious edge in both PvE and PvP. Plasma and Nuka grenades dominate in group PvE content, while Cryogenic and Pulse grenades provide tactical advantages in PvP. Managing your stash of Fallout 76 items carefully ensures you’re always prepared for any encounter. And if you ever find yourself short on resources, some players look to buy Fallout 76 items to round out their arsenal, though learning to craft and farm them will serve you best in the long run.